Published 2011/03/09
A cellular therapy product for bone reconstruction, that researcher Florelle Gindraux, Doctor of Life and Health Sciences, would like to transfer to industrial production, still needs to go through a few more research and development stages before this can happen but it does appear to have a promising future. The creation of a bone institute could give a real boost to its development.<br />
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The objective of this cellular therapy product is to reconstruct bone by bringing stromal cells (present in adults in the bone marrow, adipose tissue and cartilage, and which are capable of differentiating into bone, cartilage and tendon cells) to sites where they are missing or too few in number. In order to achieve this, the cells are combined with an osteoconductive medium and BMP (bone morphogenetic protein) molecules to promote the differentiation of marrow cells into bone cells.<br />
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Many different applications can already be envisaged, in particular related to the treatment of pseudo-arthrosis (failure of bone to knit together, occurring in 10 to 30% of long bone simple fractures), bone necrosis of the femoral head, bone loss (caused by injury or disease), revision of hip replacements and, perhaps a less obvious application, operations to lengthen arms or legs.